PAULAGORDON.com |
... conversations with People at the Leading Edgesm |
Viruses Little Helper The mosquitoes are back and they’ve brought dengue/yellow fever and
malaria with them. How did this happen? Mosquitoes were supposed to
be under
control! (Answer: underfunded public health officials were forced to
turn their attention to more pressing needs.) And now, we’ve probably
lost
the battle. [This Program was recorded January 27, 2000, in Taos, New Mexico, U.S.A.]
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Conversation 1
Dr. Barry Beaty tells about the early days of what became his life’s work -- studying arthropod and mosquito–borne diseases. He remembers how the LaCrosse Virus, which causes deadly encephalitis, played a key role. |
Conversation 2 Comparing his particular story to how science progresses, Dr. Beaty completes the saga of discovering how the LaCrosse virus lived through Wisconsin winters. This remarkable discovery enticed him into the further study of arthropods, a study which now continues at the molecular level. He describes how the apitosis regulation (programmed cell death) process works, noting we still do not know how most viral diseases are maintained during the winter. He observes the advantage the scientist who discovered the mosquito vector for LaCrosse virus had (not being captive to the prevailing scientific dogma.) Dr. Beaty explains the world-wide magnitude of the threat from dengue (close kin to yellow fever) and dengue hemorrhagic fever (dhf) and shock syndrome, as the aedes aegypti mosquito makes a huge comeback. He describes the symptoms and history of dengue and dhf. |
Conversation 3
Dengue became deadly in Southeast Asia as the area urbanized following World War II, Dr. Beaty notes, describing the disease’s progress. He offers the two theories about how dengue became one of the major pediatric diseases in Southeast Asia. Citing the return to the Americas of dengue and dhf and shock syndrome, Dr. Beaty reminds us of the great medical milestone when scientists realized mosquitoes transmit yellow fever. He describes how today’s throw-away societies invite disease, using tires as his example. He describes the major thrust of his current research program, then explains why vaccines are a problematic approach for dengue and malaria. He pronounces the worldwide explosion of dengue and malaria a disaster. |
Conversation 4
Continuing his story of how yellow fever (dengue) probably came to the Americas, Dr. Beaty offers a variety of theories of how Asia escaped. He describes how air travel has (presumably) spread all 4 serotypes of Dengue from Asia to the Americas. He tells of a major international collaborative effort to understand how genetic characteristics of aedes aegypti mosquitoes make them good vectors for dengue. He explains why he believes we have lost the war with mosquitoes. He describes how malaria is again a major health threat, noting “airport malaria” and other diseases, like West Nile virus, which benefit from expanded international travel. He reminds us of pesticides’ mixed record. |
Conversation 5
We may well have lost the battle against mosquitoes, but not the war against the diseases they and other arthropods carry, Dr. Beaty assures us. He explains how scientists are working to increase our knowledge of vectors to develop new control strategies, which he describes. Simultaneously, he reports, a global cadre of people are being trained to implement new strategies, build political will and get needed resources to control these vectors and uses yellow fever to show the importance of both. Many vector-borne diseases are socio-economic diseases, he says, clear that no one anywhere is exempt. He addresses the potential impact of his own research, talks about other arthropods and describes how scientists hope to extrapolate from their understanding of two mosquito organs. |
Conversation 6
Dr. Beaty shares why he continues to be excited about his work, using as his example the life cycle of diseases like St. Louis encephalitis. He considers possible effects global warming might have in spreading tropical diseases. |
Colorado State Univeristy's College
of Veterinary Medicine and Biomedical Science And, here's a little background information on Paula Gordon and Bill Russell, the Program co-hosts. |
Acknowledgement
Dr. C.J. Peters, Chief of Special Pathogens at the
Centers for Disease Control and Prevention (the CDC) in Atlanta, GA,
introduced us to Dr. Beaty and other renowned virologists while, simultaneously,
meeting all his obligations as co-organizer (with Dr. Michael Buckmeier)
of a virology conference in Taos, New Mexico. It’s always a pleasure
to work with Dr. Peters and we thank him. |